Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

A STUDY ON THE MECHANISM OF RADIATION PROTECTION BY 5-HYDROXYTRYPTAMINE AND TRYPTAMINE

Journal Article · · Intern. J. Radiation Biol.

Five-hydroxytryptamine (5-HT) is a powerful prophylactic against radiation in CBA mice; tryptamine is much less active. Protective doses of both compounds reduce the oxygen tension in the spleen of mice consider-ably This hypoxia in the spleen is accompanied by a notable fall in blood pressure, but for 5-HT the time courses of these effects are different. It is concluded that 5-HT and tryptamine protect mice against radiation by lowering the oxygen tension in the blood-forming organs. (auth)

Research Organization:
National Defence Research Council T.N.O., Rijswijk, Netherlands
Sponsoring Organization:
USDOE
NSA Number:
NSA-16-012939
OSTI ID:
4803439
Journal Information:
Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
Country of Publication:
Country unknown/Code not available
Language:
English

Similar Records

EFFECT OF TRYPTAMINE AND 5-HYDROXYTRYPTAMINE ON THYMOCYTES IRRADIATED IN VITRO
Journal Article · Sat Dec 31 23:00:00 EST 1960 · Compt. rend. soc. biol. · OSTI ID:4843756

INVESTIGATIONS ON A BIOLOGICAL RADIATION PROTECTOR. XXX. THE RADIATION PROTECTION EFFECT OF 5-HYDROXYTRYPTAMINE IN ANIMAL RESEARCH
Journal Article · Sat Jan 31 23:00:00 EST 1959 · Strahlentherapie (West Germany) · OSTI ID:4274773

HISTAMINE, 5-HYDROXYTRYPTAMINE, AND PROTECTION OF THE PILOSE SYSTEM OF THE SMALL MOUSE IRRADIATED IN TOTO
Journal Article · Thu Dec 31 23:00:00 EST 1959 · Compt. rend. soc. biol. · OSTI ID:4087821