Iodine-125 as a Protein Label in Immunology
Advantages of using I125 as a protein label in immunology are given. The 60-day half-life provides long shelf life for labeled materials, and the low energy dissipation rate, approximately 15% that of I131, greatly reduces radiation damage to tagged compounds. Formalin-killed Salmonella typhosa bacilli were iodinated with I125 and injected intravenously into rats. Tissues sampled for measurement of radioactivity and for autoradiography showed an average of 77% of the injected radioactivity was present in the liver and 2.5% in the spleen.
- Research Organization:
- Argonne Cancer Research Hospital, Chicago
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-012877
- OSTI ID:
- 4800475
- Journal Information:
- Science, Journal Name: Science Journal Issue: 3508 Vol. 135; ISSN 0036-8075
- Publisher:
- AAAS
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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