Cytopathic effects of deuterium oxide on the male gonads of the mouse and dog

Journal Article · Thu Feb 01 04:00:00 EST 1962 · Experimental Cell Research

DOI:https://doi.org/10.1016/0014-4827(62)90201-X· OSTI ID:4797280

Amarose, A. P.; Czajka, Dorice M.

In CF No. 1 male mice maintained on 30% deuterium oxide in their drinking water the cytological observations on the testes revealed the formation of multinucleated cells containing only spermiogenic elements. Exfoliation of spermatocytes and a disruption of the stages in the seminiferous cycle were also noted. The epididymides of the CF No. 1 mice showed, after 40 days treatment, a complete absence of spermatozoa and a great deal of debris from the tubules of the testis. C-57 black male mice showed the testicular anomalies seen in the CF No. l mice plus an absence of spermatogenic cells. Observations on the testis of the dog were similar to those seen in the CF No. 1 mice. Since no visible evidence of necrobiosis was seen in the testes or epididymides of the deuterated mice, it is suggested that the meiotic divisions in all the deuterated mice were completed but that a block in the differentiation of the daughter cells accounts for the anomalies noted.

• Research Organization: Argonne National Lab., Ill.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-012865
• OSTI ID: 4797280
• Journal Information: Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 1 Vol. 26; ISSN 0014-4827
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ANIMAL CELLS
CYTOLOGY
DOGS
GONADS
HEAVY WATER
MEIOSIS
MICE
MITOSIS
RADIATION INJURIES
WATER