COMPARISON OF PREDICTED AND MEASURED EQUILIBRIUM LEVELS FOR CHRONICALLY ADMINISTERED Cs$sup 13$$sup 7$

Journal Article · Thu Feb 01 04:00:00 EST 1962 · Health Physics (England)

OSTI ID:4794401

Richmond, C R; Furchner, J E; Trafton, G A

The biological retention of a single oral dose of Cs/sup 137/ was obtained by whole-body counting twelve 89-day-old female RF mice for 32 days. An IBM 704 computer curvefitttng procedure was then used to reduce the retention data into three exponential components, and the resultant retention function was integrated from t/sub o/ to t/sub n/to predict the Cs/sup 137/ retention by mice of the same age at any time t/sub n/ during a chronic exposure. Both the predicted build-up of body Cs/sup 137/ activity and the equilibrium level agreed reasonably well with measured values obtained by whole-body counting 89-day-old animals whose drinking water contained 0.012 mu c Cs/sup 137/ml for a 107-day period. The urinaryto-fecal excretion ratio during the period of observed equilibrium was about 9. These findings provide addittonal experimental verification for the current practice of using retention parameters obtained from acute experiments to predict equilibrium levels which would be attained during chronic exposure conditions. Retention of Cs/sup 137/ after the termination of chronic exposure did not agree with the retention pattern predicted from the original single-dose experiment, but did agree with the retention pattern predicted from a second single-dose experiment in which animals of the same age as those at the termination of the chronic ingestion period were used. The rather obscure relation between age and retention, and consequently between age and equilibrium level or radiation dose, is discussed. (auth)

• Research Organization: Los Alamos Scientific Lab., N. Mex.
• NSA Number: NSA-16-009825
• OSTI ID: 4794401
• Journal Information: Health Physics (England), Journal Name: Health Physics (England) Vol. Vol: 7; ISSN HLTPA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CESIUM 137
COMPUTERS
COUNTERS
MATHEMATICS
METABOLISM
MICE
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
URINE
WATER