THE TURNOVER OF CALCIUM AND STRONTIUM IN THE SKELETONS OF GROWING RATS ON HIGH-STRONTIUM DIETS
The deposition of strontium in the skeletons of rats of three different age groups was investigated. The rats were fed for 21 days on special diets differing from a commercial rat-diet only in that equimolar substitutions of strontium for calcium were made. At the end of the feeding period there was an approximate equilibrium between the calcium and strontium in the diet and the calcium and strontium in bone. On diets in which the strontium to calcium ratio was small, the over-all discrimination bone to diet) varied from 0.27 to 0.33, indicating a preferential deposition of calcium rather than strontium in bone. This discrimination decreased slightly with increasing age. It is postulated that equilibration of bone calcium and strontium with dietary calcium and strontium takes place only in a labile fraction of the skeleton which is computed to be 23% of the bone calcium in young rats and 6% in adults. This labile fraction is shown to be composed of about equal parts of pre-formed but still labile bone and new bone laid down over the feeding period (growth). The implications of these results on the deposition of Sr/sup 90/ in the skeleton are discussed. (auth)
- Research Organization:
- Medical Research Council, Harwell, Berks, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-017419
- OSTI ID:
- 4789839
- Journal Information:
- Intern. J. Radiation Biol., Journal Name: Intern. J. Radiation Biol. Vol. Vol: 4
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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