PERSISTENT CHROMOSOME ABERRATIONS IN IRRADIATED HUMAN SUBJECTS

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Radiation Research

DOI:https://doi.org/10.2307/3571128· OSTI ID:4789118

Bender, M A; Gooch, P C

Chromosomes of a number of men exposed to whole-body mixed gamma and fission neutron irradiation, as well as those of five unirradiated control individuals, were examined. Cytological preparations were made from short-term cultures of peripheral blood leukocytes approximately 29 months after the irradiation occurred, The doses were estimated to rarge from 22.8 to 365 rads. Five men received doses estimated to exceed 230 rads; three others received lower doses. In the five control individuals no major chromosomal abnormalities were found, other than the expected low frequencies of chromatid-type aberrations and counts other than 2n = 46. ln cells from the irradiated individuals, however, changes in both chromosome number and fortn were observed. ln the five high-dose cases, the frequency of cells with counts of other than 2n = 46 ranged from 7 to 23%. Grossly altered chromosomes, such as rings, dicentrics, and minutes, were found, often in cells with abnormal counts, with a frequency ranging from 2 to 20 per 100 cells. Two of the three low-dose individuals also show variations in number and form of their chromosomes, but at a much lower frequency than the high- dose cases, (auth)

• Research Organization: Oak Ridge National Lab., Tenn.
• Sponsoring Organization: USDOE
• NSA Number: NSA-16-017493
• OSTI ID: 4789118
• Journal Information: Radiation Research, Journal Name: Radiation Research Vol. Vol: 16
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
CHROMOSOMES
CYTOLOGY
FISSION
GAMMA RADIATION
LEUCOCYTES
MAN
NEUTRONS
RADIATION DOSES
RADIATION INJURIES