The gene encoding p120{sup cas}, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)
- St. Jude Children`s Research Hospital, Memphis, TN (United States); and others
The p120{sub cas} gene encodes a protein tyrosine kinase substrate that associates with the cell-cell adhesion protein complex containing E-cadherin and its cytoplasmic cofactors {alpha}-catenin, {beta}-catenin, and plakoglobin. Like other components of the cadherin/catenin complex, defects in p120{sup cas} may contribute to cell malignancy. We have determined the chromosomal location of the p120{sup cas} gene in human and mouse using fluorescence in situ hybridization and interspecific backcross analysis, respectively. The human p120{sub cas} gene (CTNND) is localized immediately adjacent to the centromere on the long arm of chromosome 11 in band 11q11. The murine p120{sup cas} gene (Catns) was assigned to the middle of chromosome 2. Neither locus is currently known to be associated with disease or malignancy. 17 refs., 2 figs.
- OSTI ID:
- 478845
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 31; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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