The effect of 2,4-dinitrophenol and cupferron on the production of chromatid aberrations by X-rays in Vicia faba
Journal Article
·
· Radiation Botany
The effect of 2,4-dinitrophenol (DNP) on oxygen consunpption and the production of chromatid aberrations by x rays were studied and compared with that of cupferron. The experimental material consisted of lateral root tips of the broad bean, Vicia faba. The x-ray effect at intermediate concentrations of oxygen )7%) was decreased by DNP in concentrations which stimulated respiration (10--20 mu m) and increased by DNP concentrations which inhibited respi-ration (200 mu m). The results are in agreement with the idea that there is a respiration-dependent oxygen gradient in the root. At low oxygen tension (2%) cupferron, but not DNP (100 mu m), markedly increased the frequencies of aberrations both at high (120 r/min) and at low (6.4 r/min) dose rates. Apparently, the enhancement is due to the inhibitory effect of cupferron on respiration, which would result in an elimination of the oxygen gradient in the root. In an oxygen atmosphere, both cupferron and DNP (100 mu m) increased the frequencies of x-ray-induced interchanges at low dose rates. At high dose rates the effect disappeared. It seems likely that DNP and cupferron bring about the increase by inhibiting the production of the energy-rich phosphate needed for the repair of chromosome damage. (auth)
- Research Organization:
- Univ. of Uppsala
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-16-030248
- OSTI ID:
- 4786032
- Journal Information:
- Radiation Botany, Journal Name: Radiation Botany Journal Issue: 1 Vol. 2; ISSN 0033-7560
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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