Phenotypic discordance in a family with monozygotic twins and non-syndromic cleft lip and palate

Journal Article · Mon Dec 30 00:00:00 EST 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19961230)66:4<468::AID-AJMG17>3.3.CO;2-2· OSTI ID:478540

Wyszynski, D F ^[1]; Lewanda, A F ^[2]; Beaty, T H ^[3]

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1. Johns Hopkins Univ., Baltimore, MD (United States)
2. Johnson Hopkins Hospital, Baltimore, MD (United States)
3. Johns Hopkins Univ., Balitomre, MD (United States)

Despite considerable research, the cause of non-syndromic cleft lip with or without cleft palate (NSCLP) is still an enigma. Case-control and cohort studies have searched for environmental factors that might influence the development of this common malformation, such as maternal cigarette smoking, periconceptional supplementation of folic acid and multivitamins, agricultural chemical use, and place of residence, among others. However, these studies are subject to numerous biases, and their results have often been contradictory and inconclusive. 41 refs., 1 fig.

• OSTI ID: 478540
• Journal Information: American Journal of Medical Genetics, Vol. 66, Issue 4; Other Information: PBD: 30 Dec 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CONGENITAL MALFORMATIONS
GENETICS
GENES
GENETIC MAPPING
HUMAN CHROMOSOMES
PATIENTS
PHENOTYPE
HEREDITARY DISEASES
POLYMERASE CHAIN REACTION
BIOLOGICAL MARKERS