Phenotypic discordance in a family with monozygotic twins and non-syndromic cleft lip and palate

Journal Article · Mon Dec 30 04:00:00 EST 1996 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/(SICI)1096-8628(19961230)66:4<468::AID-AJMG17>3.3.CO;2-2· OSTI ID:478540

Wyszynski, D F ^[1]; Lewanda, A F ^[2]; Beaty, T H ^[3]

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1. Johns Hopkins Univ., Baltimore, MD (United States)
2. Johnson Hopkins Hospital, Baltimore, MD (United States)
3. Johns Hopkins Univ., Balitomre, MD (United States)

Despite considerable research, the cause of non-syndromic cleft lip with or without cleft palate (NSCLP) is still an enigma. Case-control and cohort studies have searched for environmental factors that might influence the development of this common malformation, such as maternal cigarette smoking, periconceptional supplementation of folic acid and multivitamins, agricultural chemical use, and place of residence, among others. However, these studies are subject to numerous biases, and their results have often been contradictory and inconclusive. 41 refs., 1 fig.

• OSTI ID: 478540
• Journal Information: American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 4 Vol. 66; ISSN 0148-7299; ISSN AJMGDA
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
CONGENITAL MALFORMATIONS
GENES
GENETIC MAPPING
GENETICS
HEREDITARY DISEASES
HUMAN CHROMOSOMES
PATIENTS
PHENOTYPE
POLYMERASE CHAIN REACTION