STUDIES ON CLINICAL USE OF COLLOIDAL YTTRIUM-90 (Y$sup 90$)

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Nippon Igaku Hoshasen Gakkai Zasshi (Japan)

OSTI ID:4785359

Obayashi, Y

The distribution of colloidal Y/sup 90/ following intratumoral and intracavitary administration in the form of Y/sup 90/ + Fe(OH)/sub 3/ was studied, using normal and Yoshida-sarcomabearing rats and Ehrlich-ascites-bearing mice. Colloidal Y/sup 980/ injected intramuscularly and intratumorally, remained for over 90% at the injection site for a long time. After intracavitary administration, Y/sup 90/ remained locally in the injected cavity. The Yoshida- sarcoma tumors, transplanted subcutaneously, were treated by interstitial injection of colloidal Y/sup 90/, and tumoricidal effects were observed in 10 out of 14 cases. Six clinical cases of superficial malignant tumors were treated with good effect, in 5 cases by injection of colloidal Y/sup 90/ interstitially. Y/sup 90/ was used in the treatment of 21 cases of malignant effusions (14 pleural and 7 peritoneal); of the 14 patients, 10 showed good control of the fluid, and 3 showed no improvement of the disease. The seven cases were treated intraperitoneally with poor results. (Abstr. Japan Med., 2, No. 2, Feb. 1962).

• Research Organization: Yokohama Univ. School of Medicine, Japan
• NSA Number: NSA-16-014438
• OSTI ID: 4785359
• Journal Information: Nippon Igaku Hoshasen Gakkai Zasshi (Japan), Journal Name: Nippon Igaku Hoshasen Gakkai Zasshi (Japan) Vol. Vol: 20; ISSN NHGZA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
CANCER
COLLOIDS
GRAFTS
MAN
MEDICINE
QUANTITY RATIO
RADIOTHERAPY
RATS
TISSUES
TRANSPLANTS
TUMORS
YTTRIUM 90