THE ROLE OF THE SUPERMOLECULAR STRUCTURE OF DNA IN THE RADIATION INJURY OF CELLS (in Russian)
It was reported previously that immediately after irradiation of various organisms with a lethal dose, a distinct break is observed in supermolecular structure of DNA (Radiobiologiya 1o 761 (1961)). Identical observations were made with both radiation sensitive tissues, such as the bone marrow of chickens, and with resistant tissues, such as erythrocytes. This problem was further investigated by exami-ni-ng the kinetics of the break of the supermolecular structure of DNA in the thymus and the liver of the rat as a function of the dose and of the time elapsed since the irradiation as these tissues differ greatly in their radiation sensitivity. Identical breaks in the supermolecular structure were observed; the importance of the effect depended on the dose. Shielding the breast region of the animal prevented appearance of the break in the thymus. The initial latent stage was followed by a complete decomposition of the structure in the thymus in the case of irradiation with a lethal dose (500, 1000, and 5000 r). Irradiation at 50 and 200 r resulted in a partial break after 4 hours, remaining at that level for long periods. In the liver, exposure to lethal dose resulted in a reversible break, although it was irreversible at very high dose levels. The radiation sensitivity thus seems to depend on the basic composition of the tissue and on the ability of the tissue to recreate this structure. (TTT)
- Research Organization:
- Inst. of Biological Physics, Academy of Sciences, Moscow
- NSA Number:
- NSA-16-030254
- OSTI ID:
- 4783954
- Journal Information:
- Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 2; ISSN RADOA
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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