THE MUTAGENIC EFFECT OF VANILLIN AND OF SOME OF ITS DERIVATIVES (in Russian)
A dose of 3 to 60 Mgs of crystalline vanillin was added to nutrient broth for Drosophila melanogaster in the early larval stage (48 hours old) or as grown males. The progeny of the flies was analyzed for the number of lethal mutations associated with sex. An increase in mutagenesis by a factor of four was observed. The 5-iodovanillin and 5-bromovanillin derivates had an even higher mutagenic effect than vanillin, particularly on the full-grown sex cells (spermatogonia). The mutagenic effect of vanillin was increased by dissolving it in a 2M solution of triacetin readily soluble. The incidence of melanitic cancer was increased significantly by adding vanillin to the diet of an insect. The results are of significance because of the widespread use of vanillin in the food industry. Vanillin acts as an antioxidant, and interacts with various oxidases. (TTT)
- Research Organization:
- Inst. of Chemical Physics, Academy of Sciences, USSR
- NSA Number:
- NSA-17-001214
- OSTI ID:
- 4777120
- Journal Information:
- Doklady Akad. Nauk SSSR, Vol. Vol: 146; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- Russian
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