RELATIVE VALUE OF THE CRITERIA PERMITTING THE STUDY OF THE RADIATION SYNDROME IN LABORATORY ANIMALS

Journal Article · Fri Jun 01 04:00:00 EDT 1962 · Revue Canadienne de Biologie (Canada)

OSTI ID:4772737

Ghys, R

The criteria most often used to estimate results for radiations of different nature are determined. Among the tests usable on a large range of doses and not necessitating the sacrifice of the animals, the most significant is the evolution of the number of platelets; the simplest to follow is the weight. Four criteria, used simultaneously, give a maximum of information in spite of their technical simplicity: weight, food consumption, hematocrit, and the number of blood platelets. The syndrome observed after a non-fractionated, whole-body irradiation is described, and its two principal conponents are studied. In the digestive phase, death is caused by the loss of liquids and electrolytes. In the hematological phase, death usually results from the inhibition of the reproduction of one or several basic cellular lines. The symptoms permitting the result of an irradiation to be predicted are given. A favorable evolution is always associated with an active anabolism before irradiation. After irradiation, a hemoconcentration, a large loss of weight, a drop in the rate of hemoglobin by red blood cells, or a marked thrombocytopenia are poor prognostics. A large drop of the polynuclear leukocytes on the second day is always a good sign. (tr-auth)

• Research Organization: Universite Liege
• NSA Number: NSA-17-001351
• OSTI ID: 4772737
• Journal Information: Revue Canadienne de Biologie (Canada), Journal Name: Revue Canadienne de Biologie (Canada) Vol. Vol: 21; ISSN RCBIA
• Country of Publication: Country unknown/Code not available
• Language: French

Related Subjects

ANIMALS
BIOLOGY AND MEDICINE
BLOOD CELLS
BODY
HEMOGLOBIN
IONS
IRRADIATION
LEUCOCYTES
LIQUIDS
METABOLISM
PHYSIOLOGY
PLATELETS
QUANTITY RATIO
RADIATION DOSES
RADIATION SICKNESS
REPRODUCTION
STANDARDS
STOMACH
SURVIVAL TIME
TESTING
VARIATIONS
WEIGHT