A gene for nonspecific X-linked mental retardation (MRX41) is located in the distal segment of Xq28
Journal Article
·
· American Journal of Medical Genetics
DOI:https://doi.org/10.1002/(SICI)1096-8628(19960712)64:1<131::AID-AJMG22>3.3.CO;2-T·
OSTI ID:476922
- Erasmus Univ., Rotterdam (Netherlands); and others
We report on a family in which non-syndromal mild to moderate mental retardation segregates as an X-linked trait (MRX41). Two point linkage analysis demonstrated linkage between the disorder and marker DXS3 in Xq21.33 with a lod score of 2.56 at {theta} = 0.0 and marker DXS1108 in Xq28 with a lod score of 3.82 at {theta} = 0.0. Multipoint linkage analysis showed that the odds for a location of the gene in Xq28 vs. Xq21.33 are 100:1. This is the fourth family with non-specific X-linked mental retardation with Xq28-qter as the most likely gene localization. 16 refs., 2 figs., 1 tab.
- OSTI ID:
- 476922
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 1 Vol. 64; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
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