THE EFFECT OF X IRRADIATION ON THE SPREAD OF TICK-BORNE ENCEPHALITIS VIRUS THROUGH THE REGIONAL LYMPHATIC SYSTEM
Studies were made to ascertain whether changes caused in the lymphatic system by x radiation would affect penetration of the virus through the lymphatic system into the blood stream. Mice given 300 or 600 r were inoculated intraplantarly either on the 5th or 13th day after irradiation. Irradintion with either single dose led to a decrease in virus in regional lymph nodes and blood. if the animals were inoculated 5 days after irradiation. The decrease in virus titer was most marked in mice irradiated with a dose of 600 r and inoculated with 1500 LD/sub 50/ of virus. The titer of virus in the organs examined remained unaffected as long as the virus did not penetrate the regional lymphatic system into blood. The slower penetration of virus through the lymphatic system of irradiated mice was apparently caused by general changes in the lymphatic system, although it appears probable that an important factor was also the decreased number of lymphocytes, which may act as carriers of virus. (H.H.D.)
- Research Organization:
- Czechoslovak Academy of Sciences, Prague
- NSA Number:
- NSA-17-005786
- OSTI ID:
- 4768349
- Journal Information:
- Acta Virol. (Prague), Vol. Vol: 6; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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