Chromosomal localization of murine and human oligodendrocyte-specific protein genes

Journal Article · Sat Jun 01 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0278· OSTI ID:476787

Bronstein, J M; Wu, S; Korenberg, J R ^[1]

---

1. UCLA School of Medicine, Los Angeles, CA (United States); and others

Oligodendrocyte-specific protein (OSP) is a recently described protein present only in myelin of the central nervous system. Several inherited disorders of myelin are caused by mutations in myelin genes but the etiology of many remain unknown. We mapped the location of the mouse OSP gene to the proximal region of chromosome 3 using two sets of multilocus crosses and to human chromosome 3 using somatic cell hybrids. Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions. 24 refs., 2 figs.

• DOE Contract Number: FG03-92ER61402
• OSTI ID: 476787
• Journal Information: Genomics, Vol. 34, Issue 2; Other Information: PBD: 1 Jun 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
MYELIN
GENE MUTATIONS
GENETIC MAPPING
DNA SEQUENCING
HEREDITARY DISEASES
ETIOLOGY
MAN
NERVOUS SYSTEM DISEASES
PHENOTYPE
HUMAN CHROMOSOME 3
CHROMOSOMES
MICE
PROTEINS
CENTRAL NERVOUS SYSTEM
SOMATIC CELLS
HYBRIDIZATION
DNA HYBRIDIZATION
FLUORESCENCE
NUCLEOTIDES