Chromosomal localization of murine and human oligodendrocyte-specific protein genes
- UCLA School of Medicine, Los Angeles, CA (United States); and others
Oligodendrocyte-specific protein (OSP) is a recently described protein present only in myelin of the central nervous system. Several inherited disorders of myelin are caused by mutations in myelin genes but the etiology of many remain unknown. We mapped the location of the mouse OSP gene to the proximal region of chromosome 3 using two sets of multilocus crosses and to human chromosome 3 using somatic cell hybrids. Fine mapping with fluorescence in situ hybridization placed the OSP gene at human chromosome 3q26.2-q26.3. To date, there are no known inherited neurological disorders that localize to these regions. 24 refs., 2 figs.
- DOE Contract Number:
- FG03-92ER61402
- OSTI ID:
- 476787
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 34; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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