THE EFFECTS OF ULTRAVIOLET LIGHT AND GAMMA RAYS ON CELL LIPIDS AND THE PHYSIOLOGICAL ACTION OF IRRADIATED LIPIDS. Final Report

Technical Report · Mon Mar 26 04:00:00 EST 1962

OSTI ID:4758040

Bernheim, F; Wilbur, K M

Results are summarized from a series of studies on the effects of ultraviolet and ionizing radiation on the oxidation of cell lipids. It was shown that both in vitro and in vivo radiation produced oxidation products of lipids that inhibited the activity of certain oxidative enzymes, depolymerized desoxyribonucleoprotein, inhibited the division of marine eggs, and retarded bacterial growth. The presence of antioxidant activity was also demonstrated in tissues. The significant feature of antioxidant compounds with respect to the biological effects of radiation was shown to be the inhibition of the oxidation of lipids. In irradiated animals the antioxidant activity of the intestinal mucosa and the activity of phospholipase decreased. Experiments showed that radiation had not destroyed the enzyme but had inactivated the activator. Results are also summarized from a study on the effects of ionizing radiation on cell growth and protein synthesis in yeast. (C.H.)

• Research Organization: Duke Univ., Durham, N.C.
• NSA Number: NSA-17-002833
• OSTI ID: 4758040
• Report Number(s): TID-17225
• Country of Publication: United States
• Language: English

Related Subjects

ANIMAL CELLS
BACTERIA
BIOCHEMISTRY
BIOLOGY AND MEDICINE
EMBRYOS
ENZYMES
GAMMA RADIATION
INTESTINE
LIPIDS
NUCLEIC ACIDS
OXIDATION
PROTEINS
RADIATION EFFECTS
TISSUES
ULTRAVIOLET RADIATION
YEASTS