MECHANISMS OF INJURY AND RECOVERY FROM WHOLE AND PARTIAL BODY EXPOSURE TO IONIZING RADIATION
The lethality of ionizing radiation is dependent on dose rate, as well as total dose. In the dog, the LD 50/60 dose is increased by 50% when the rate is dropped from 10 r/ minute to 1 r/minute. The half recovery time for the dog is 8 to 9 days. Residual damage 3 to 9 months after an initial whole-body exposure amounts to 15 to 20% of the LD-50 as evidenced by a shift in the dosage mortality curve. Leukoeyte changes reflect injury and recovery patterns, and leukocyte depression is related to radiation dosage. Fractionated exposures to four equal daily doses produces the same leukocytc depression as a single dose equal to the sum of the four. Aftea serial whole-body exposure, leukocyte recovery is progressively depressed. Hematologic aecovery occurs earliest among upper-body radiation survivors, more slowly after whole-body, and intermediate after lower-body radiation. Recovery appears to be related to the metabolic activity of the tissue. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- NSA Number:
- NSA-16-032736
- OSTI ID:
- 4757091
- Report Number(s):
- UR-615
- Country of Publication:
- United States
- Language:
- English
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