CLINICAL ASPECTS OF FRACTIONATION AND DOSE-TIME RELATIONSHIPS
Journal Article
·
· Brit. J. Radiol.
Recent research in radiobiology indicates that many dffferent kinds of mammalian cell, both normal and malignant, show similar radiosensitivity with respect to loss of reproductfve integrity, if at the same oxygen tension. The shoulder at the begfnning of the dose-response curve implies that fractionation must reduce the efficiency of irradiation, and with a relatively greater loss of effect on hypoxic cells, probably present in many tumors. Nevertheless, clinical experience with extended fractionation methods confirms their value. It is suggested that this is due to differences in the cell-population kinetics of normal and malignant tissue. Such differences can be even further exploited by split-course methods, making possible high tumor doses with reduced normal tissue damage. (auth)
- Research Organization:
- Swansea Hospital, Eng.
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-015659
- OSTI ID:
- 4755790
- Journal Information:
- Brit. J. Radiol., Journal Name: Brit. J. Radiol. Vol. Vol: 36
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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