In Vitro Detection of Characteristic Differences in Radiation Sensitivity of Female Genital Cancers

Journal Article · Mon Jan 01 04:00:00 EST 1962 · Obstetrical and Gynecological Survey

DOI:https://doi.org/10.1097/00006254-196208000-00033· OSTI ID:4750771

LUDOVICI, PETER P.; MILLER, NORMAN F.

BS>By a standardized assay technic in which cell monolayers were irradiated at different dose levels (100 to 1200 r) on the 4th culture day and cell counts carried out 4 days later, the radiation sensitivities of 37 cell strains, derived from female patients with various genital cancers and from normal individuals, were assessed. These 37 cell strains had certain patterns of radiation sensitivity which, in general, appear to be consistent with the generally accepted radiosensitivity of the tumors from which the cell strains arose. Cell strains from squamous-cell carcinomas of the cervix as a group were at least twice as sensitive as those from other squamous-cell carcinomas of the female genital tract. Cell strains derived from carcinomas of the ovary, vagina, and vulva were almost equally resistant to radiation. As expected, cell strains derived from benign tissues were the most highly resistant to radiation, normal fibroblastic strains being more resistant than normal epithelial strains. (H.H.D.)

• Research Organization: Univ. of Michigan Medical School, Ann Arbor
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-005865
• OSTI ID: 4750771
• Journal Information: Obstetrical and Gynecological Survey, Journal Name: Obstetrical and Gynecological Survey Journal Issue: 4 Vol. 17; ISSN 0029-7828
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CANCER
CYTOLOGY
GONADS
MAN
MEASURED VALUES
MEDICINE
OVARIES
RADIATION DOSES
RADIOSENSITIVITY
RADIOTHERAPY
SEX
TISSUES
VULVA