THE USE OF THE MASS SPECTROMETER FOR THE QUANTITATIVE ANALYSIS OF MIXTURES OF AMINO ACIDS
The quantitative analysis of a low vapor pressure unstable solid mixture of amino acids is possible by putting the solid mixture in a crucible which is then placed directly into the ionization chamber of a mass spectrometer. Relative sensitivities for the various acids in a mixture can be established by the proper use of a particular amino acid as an internal calibrating standard. The success of the method depends upon: the reproducibility of the mass spectra of the pure components, the ideal vapor pressure behavior of the solid mixture, and the preparation of an intimate solid mixture by rapid freezing of the water solution of the acids with subsequent vacuum sublimation of the ice and ball- milling the dried mixture. (auth)
- Research Organization:
- Ames Lab., Ames, Iowa
- NSA Number:
- NSA-17-017986
- OSTI ID:
- 4744656
- Report Number(s):
- IS-495; 0003-2670
- Journal Information:
- Analytica Chimica Acta (Netherlands) , Journal Name: Analytica Chimica Acta (Netherlands) Vol. Vol: 28; ISSN ACACA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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