Dietary accumulation of C{sub 12}- and C{sub 16}-chlorinated alkanes by juvenile rainbow trout (Oncorhynchus mykiss)
- Univ. of Manitoba, Winnipeg, Manitoba (Canada). Dept. of Soil Science
- Department of Fisheries and Oceans, Winnipeg, Manitoba (Canada). Freshwater Inst.
- Stockholm Univ. (Sweden)
Dietary exposures using juvenile rainbow trout (Oncorhynchus mykiss) were conducted with four {sup 14}C-polychlorinated alkanes in order to measure bioaccumulation parameters, metabolism, and tissue distributions. These chlorinated alkanes are found in industrial chlorinated paraffin (CP) products, although their method of synthesis is different than that of CPs. Trout were exposed for 40 d to nominal concentrations of 20 and 200 ng/g of each chlorinated alkane, as well as to 2,000 ng/g for C{sub 16}H{sub 21}Cl{sub 13}, followed by an elimination period of up to 173 d. Whole-body half-lives in the rainbow trout ranged from 37 {+-} 2 d for C{sub 16}H{sub 31}Cl{sub 3} to 87 {+-} 11 d for C{sub 12}H{sub 16}Cl{sub 10}, and assimilation efficiencies of C{sub 16}H{sub 21}Cl{sub 13} to 2.15 for C{sub 12}H{sub 16}Cl{sub 10}. Accumulation of C{sub 16}H{sub 21}Cl{sub 13} may be sterically hindered due to its large molecular size. Lower chlorinated alkanes, e.g., C{sub 16}H{sub 31}Cl{sub 3}, had shorter half-lives than highly chlorinated alkanes, probably due to increased metabolism. High-performance liquid chromatography {sup 14}C analysis of fish tissue extracts revealed that the chlorinated alkane mixtures were selectively biotransformed with certain unknown components persisting in tissues. Lower chlorinated alkanes had greater proportions of polar {sup 14}C, which implies greater metabolism of these compounds. Highly chlorinated, short-carbon-chain (C{sub 10-13}) alkanes and lower chlorinated, medium-carbon-chain (C{sub 14-18}) alkanes appear to have the greatest potential for biomagnification among CP components. No reduced growth rates or hepatic monooxygenase enzyme induction were seen in any of the chlorinated alkane exposures when compared with controls.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 474297
- Journal Information:
- Environmental Toxicology and Chemistry, Vol. 15, Issue 10; Other Information: PBD: Oct 1996
- Country of Publication:
- United States
- Language:
- English
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