Congenital hypothyroidism in infant following maternal I131 therapy
Journal Article
·
· Journal of Pediatrics
The case history is cited of an infant with congenital hypothyroidism whose mother had received 14.5 mC I131 as therapy for Graves' disease during the end of the first trimester of pregnancy. It was estimated that the fetal thyroid received around 250000 rad, contrasted with the usual estimated 10000 to 20000 rad for the thyroid of adults treated for hyperthyroidism. The infant when seen at the age of 18 months showed marked retardation in growth and in physical and mental development. The danger of I131 therapy to women of child-bearing age is emphasized. An extensive discussion is given on the hazards of radioactive isotopes in the environment to children, the description of the fallout pattern of Sr90 in the U. S. and the difficulties in accurately estimating its danger to children, several possible approaches to the reduction of dietary Sr90, I131 contamination of the environment, and the use of nonradioactive iodide to interfere with the thyroidal uptake of I131. The case record data of 4 other infants with congenital hypothyroidism whose mothers underwent I131 therapy during pregnancy are also cited. Recommendations are provided for avoiding radiation injury to the fetal thyroid as well as for generally lowering the fetal, infant, and maternal incorporation of radionuclides of fallout origin.
- Research Organization:
- State Univ. of New York, Syracuse
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-017856
- OSTI ID:
- 4738054
- Journal Information:
- Journal of Pediatrics, Journal Name: Journal of Pediatrics Journal Issue: 1 Vol. 62; ISSN 0022-3476
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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