ACUTE MYELOGENOUS LEUKEMIA COMPLICATING RADIOACTIVE IODINE THERAPY OF THYROID CANCER. REPORT OF A CASE

Journal Article · Fri Mar 01 04:00:00 EST 1963 · Am. J. Roentgenol., Radium Therapy Nucl. Med.

OSTI ID:4734834

Lewallen, C G; Godwin, J T

The clinical, hematologic, and pathologic findings of a patient with thyroid cancer who developed leukemia following radioactive iodine therapy are presented. With respect to iodine metabolism, the tumor was highly functional and histologically was well differentiated. The metastatic deposits were primarily skeletal, Acute myelogenous leukemia of the aleukemic variety developed after the patient had received a total of 805 mC of I/sup 131/ therapeutically over a 4-yr period. The total radiation dose to the blood was estimated to be 1600 rads. The total biologically effective radiation dose to the bone marrow, was estimated to be about 44% of the radiation dose to the blood. The clinical and hematologic features of the case consonant with a radiation etiology of the leukemia are discussed and reference is made to 9 additional cases in which leukemia complicating radioactive iodine therapy of thyroid cancer was previously described. (P.C.H.)

• Research Organization: Brookhaven National Lab., Upton, N.Y.; and National Inst. of Arthritis and Metabolic Diseases, Bethesda, Md.
• NSA Number: NSA-17-013998
• OSTI ID: 4734834
• Journal Information: Am. J. Roentgenol., Radium Therapy Nucl. Med., Journal Name: Am. J. Roentgenol., Radium Therapy Nucl. Med. Vol. Vol: 89
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BLOOD
BONE MARROW
BONES
CANCER
IODINE 131
LEUKEMIA
MAN
MEDICINE
METASTASES
RADIATION DOSES
RADIATION INJURIES
RADIOTHERAPY
THYROID