RADIONUCLIDE MINERAL STUDIES. 5. THE RELATION OF SERUM ALKALINE PHOSPHATASE TO Ca$sup 45$ METABOLISM IN THE CHICK AS INFLUENCED BY AGE, VITAMIN D$sup 3$, AND TREATMENT
The relation of serum alkaline phosphatase to Ca/sup 45/ metabolism in the chick was studied, as well as the influence of age, vitamin D/sub 3/, and dosing procedure on the relation. In White Leghorn chicks the absence of dietary vitamin D/sub 3/ was associated initially with higher enzyme activity, lower Ca/ sup 45/ mineralization, and tibia ash content. After 2 weeks of age, however, a trend suggesting correction of the deficiency was observed until 3 weeks of age. Serum alkaline phosphatase activity increased subsequent to the oral administration of water to the chick. The effect does not manifest itself early in life, and was not observed until the chicks were st run. Concent 1 week of age. Previously injected Ca/sup 45/ was removed from bone into the blood of chicks subsequent to giving distilled H/sub 2/O. This was indicated by decreased bone Ca/sup 45/, increased total serum Ca, and serum Ca/sup 45/ and was paralleled by increased serum alkaline phosphatase activlty. The variabillty of serum alkaline phosphatase activity in the chick may be due to its apparent role in serum Ca homeostasis. Any factor lowering the serum Ca level appeared to initiate bone resorption, which may be triggered by parathyroid hormone. Any factor leading to decalcification induces and may depend upon increased production of alkaline phosphatase. (H.H.D.)
- Research Organization:
- Univ. of West Virginia, Morgantown
- Sponsoring Organization:
- USDOE
- NSA Number:
- NSA-17-021450
- OSTI ID:
- 4728132
- Journal Information:
- Poultry Sci., Journal Name: Poultry Sci. Vol. Vol: 41
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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