CHROMOSOME BREAKAGE AND NUCLEAR INJURIES AS CAUSES OF DEATH OF CELLS EXPOSED TO IONIZING RADIATIONS

Journal Article · Sat Apr 01 04:00:00 EST 1961 · Pathol. Biol., Semaine Hop.

OSTI ID:4725877

Howard, A

Nuclear sensitivity of cells was demonstrated by experiments in which cells were partially irradiated, from nuclear transfer experiments, from the relation between radiation dose and number of chromosome breaks induced, and form observation on multinucleate cells. Chromosome breaks resulting from exposure of cells to ionizing radiations, or to a variety of chemicals, can be detected only in cells that divide after the breaks are induced. Other kinds of nuclear effects (interruption, postponement, or slowing down of DNA synthesis, mitotic delay, nuclear enlargement, pycnosis) can be seen in the absence of division. Although it is not known to what extent the effects may be causally related to each other or to the induction of chromosome breaks, breakage of chromosomes per se does not appear to be a cause of cell death. It is apparent that genetic loss due to chromosome breakage is an important, but not the only, cause of cell death following irradiation. (TCO)

• Research Organization: Mount Vernon Hospital, Northwood, Middx, Eng.
• NSA Number: NSA-17-023128
• OSTI ID: 4725877
• Journal Information: Pathol. Biol., Semaine Hop., Journal Name: Pathol. Biol., Semaine Hop. Vol. Vol: 9
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHEMICALS
CHROMOSOMES
GENETICS
IONIZATION
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION DOSES
RADIATION INJURIES
RADIOSENSITIVITY