Induction of granulocytic differentiation in a mouse model by benzene and hydroquinone
Journal Article
·
· Environmental Health Perspectives
- Jefferson Medical College, Philadelphia, PA (United States)
Chronic exposure of humans to benzene causes acute myelogenous leukemia (AML). The studies presented here were undertaken to determine whether benzene, or its reactive metabolite, hydroquinone (HQ), affects differentiation of myeloblasts. Benzene or HQ administered to C57BL/6J mice specifically induced granulocytic differentiation of myeloblasts. The ability of these compounds to induce differentiation of the myeloblast was tested directly using the murine interleukin 3 (IL-3)-dependent 32D.3 (G) myeloblastic cell line, and the human HL-60 promyelocytic leukemia cell line. 37 refs., 8 figs., 4 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 472169
- Report Number(s):
- CONF-9506288--; CNN: Grant R819301
- Journal Information:
- Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: Suppl.6 Vol. 104; ISSN 0091-6765; ISSN EVHPAZ
- Country of Publication:
- United States
- Language:
- English
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Sat Nov 30 23:00:00 EST 1996
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OSTI ID:472157