METABOLIC BALANCE AND Sr$sup 85$ STUDY OF A PATIENT WITH MULTIPLE MYELOMA TREATED WITH CORTICOSTEROIDS AND ANDROGENS
A long-term metabolic balance investigation in a 40-yrold man was undertaken to evaluate the efficacy or inefficacy of combined corticoid-androgen therapy in a single patient. After a suitable control period the patient was given prednisone alone, then prednisone plus testosterone propionate and finally ACTH plus testosterone propionate. Sr/sup 85/ excretion studies were done in conjunction with the metabolic tests to assist in interpretation of Ca metabolism. Clinically, diminution of bone pain, increase in physical activity, rise in hematocrit, and loss of weight were effected by prednisone alone. Combined therapy with testosterone reversed the weight loss and further increased hematocrit levels. Bone pain remained diminished. The ACTH-testosterone combination, however, appeared to be superior in that physical activity rose above that with the other 2 treatments. Negative Ca balances were observed throughout the study. Further lessening of negative Ca balance was seen with the ACTH-testosterone combination. Sr/sup 85/ tests showed that there was considerable reduction in the daily loss of bone mineral with the addition of testosterone therapy to either prednisone or ACTH. The findings are in accord with the observed reduction in magnitude of the negative Ca balance. Comparisons of total excretion of Sr/sup 85/ also show that the greatest reduction in loss of bone mineral occurred with the combination of ACTH and testosterone, 66% of the total intravenous dose of Sr/sup 85/ being excreted within 15 days compared with 84% during prednisone or 73% during prednisone and testosterone treatment. (H.H.D.)
- Research Organization:
- Univ. of California, Los Angeles
- NSA Number:
- NSA-17-021438
- OSTI ID:
- 4719060
- Journal Information:
- Metab., Clin. Exptl., Vol. Vol: 11; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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