ADENOCARCINOMA OF THE ENDOMETRIUM FOLLOWING RADIATION THERAPY AND ASSOCIATED WITH HILUS CELL HYPERPLASIA

Journal Article · Wed Nov 01 04:00:00 EST 1961 · American Journal of Obstetrics and Gynecology (U.S.)

OSTI ID:4717037

Schuldenfrei, R; Janovski, N A; Ober, W B

The case history is presented concerning a 65-yr-old woman in whom a malignant uterine tumor was found 28 yr after pelvic x irradiation for a benign condition. The estimated mid-pelvis dose was 1350 r. The endometrial adenocarcinoma was accompanied by a proliferation of ovarian hilus cells. The patient had also developed a cecal adenocarcinoma 16 yr after radiotherapy. It is suggested that x irradiation may have been-primarily responsible for both tumors and that hilar hyperplasia may have provided endocrine stimulation acting as a secondary factor in the induction of the endometrial cancer. Thus, irradiation may have acted as the initiating stimulus and excessive hormone output as the promoting factor or cocarcinogen. An extensive review is made of the literature of cases of this type. (H.H.D.)

• Research Organization: Albert Einstein Coll. of Medicine, New York
• NSA Number: NSA-17-017792
• OSTI ID: 4717037
• Journal Information: American Journal of Obstetrics and Gynecology (U.S.), Journal Name: American Journal of Obstetrics and Gynecology (U.S.) Vol. Vol: 82; ISSN AJOGA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
BIOLOGY AND MEDICINE
CANCER
CARCINOGENESIS
GONADS
HORMONES
MAN
RADIATION DOSES
RADIOTHERAPY
SEX
TISSUES
UTERUS
X RADIATION