Patient-specific dosimetry of indium-111- and yttrium-90-labeled monoclonal antibody CC49

Journal Article · Tue Apr 01 04:00:00 EST 1997 · Journal of Nuclear Medicine

OSTI ID:471490

Leichner, P K; Akabani, G; Colcher, D ^[1]

---

1. Univ. of Nebraska Medical Center, Omaha, NE (United States); and others

The objective of this work was to develop patient-specific dosimetry for patients with metastatic gastrointestinal tract cancers who received {sup 111}In-CC49 IgG for imaging before therapy with {sup 90}Y-CC49 IgG. Whole-body imaging of 12 patients, who received 111-185 MBq (3-5 mCi) of {sup 111}In-CC49, commenced in < 2 hr postinfusion and was continued daily for 4-5 days. SPECT data were acquired at 24 and 72 hr to determine the range of {sup 111}In-CC49 activity concentrations in tumors and normal organs. Time-activity curves were generated from the image data and scaled from {sup 111}In-CC49 to {sup 90}Y-CC49 for dosimetric purposes. Absorbed-dose calculations for {sup 90}Y-CC49 included the mean and range in tumor and normal organs. Computed 90Y-CC49 included the mean and range in tumor and normal organs. Computed {sup 90}Y-CC49 activity concentrations were compared with measurements on 10 needle biopsies of normal liver and four tumor biopsies. In 9 of 10 normal liver samples, the range of computed {sup 90}Y-CC49 activity concentrations bracketed measured values. This was also the case for 3 of 4 tumor biopsies. Absorbed-dose calculations for {sup 90}Y-CC49 were based on patients` images and activities in tissue samples and, hence, were patient-specific. For the radiolabeled antibody preparations used in this study, quantitative imaging of {sup 111}In-CC49 provided the data required for {sup 90}Y-CC49 dosimetry. The range of activities in patients` SPECT images was determined for a meaningful comparison of measured and computed values. Knowledge of activity distributions in tumors and normal organs was essential for computing mean values and ranges of absorbed dose and provided a more complete description of the absorbed dose from {sup 90}Y-CC49 than was possible with planar methods. 27 refs., 1 fig., 3 tabs.

• DOE Contract Number: FG02-91ER61195
• OSTI ID: 471490
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 4 Vol. 38; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
DIAGNOSTIC TECHNIQUES
DOSIMETRY
GASTROINTESTINAL TRACT
IMAGES
INDIUM 111
MONOCLONAL ANTIBODIES
NEOPLASMS
PATIENTS
RADIOIMMUNOTHERAPY
RADIONUCLIDE KINETICS
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
UPTAKE
YTTRIUM 90