INHIBITION OF THE IMMUNE RESPONSE BY CORTISONE, AND ITS POSSIBLE RELATION TO THE SIMILAR ACTION OF X RAYS AND ANTI-METABOLIC DRUGS
Journal Article
·
· Proc. Internat. Symposium Tissue Transplantation, Santiago, Chile, 20 Aug.-2 Sept. 1961
OSTI ID:4701205
Cortisone administered to mice during primary immunization inhibited the production of isoantibody (hemagglutinins). The inhibition initiated during primary immunization persisted for a prolonged period, as evidenced by the production of a very low titered antibody or no detectable antibody, after secondary immunization, this time without cortisone. Cortisone administered only during the period of secondary immunization had little or no inhibitory effect on isoantibody production. The data are in general agreement with the effects of x irradiation and some antimetabolic drugs on the immune response. The inhibitory effectiveness of the agents is dependent on the timing between their administration and injection of antigen, and on their relative dosages. This is most clearly shown with x irradiation and the method of cell transfer techniques. The data thus derived are consistent with the conclusion that 2 qualitatively different phases are involved in antibody formation, an inductive phase, during which the stage is set for antibody synthesis, but during which there is no detectable antibody formed, and a productive phase. The first phase is sensitive to radiation and radiomimetic drugs; the second phase is not. The influence of the agents on both antibody production and homograft survival is discussed. All 3 classes of immuneinhibitory agents, when administered by themselves, delay the homograft reaction, but do not completely abrogate it. (TCO)
- Research Organization:
- Roscoe B. Jackson Memorial Lab., Bar Harbor, Me.
- NSA Number:
- NSA-17-024960
- OSTI ID:
- 4701205
- Journal Information:
- Proc. Internat. Symposium Tissue Transplantation, Santiago, Chile, 20 Aug.-2 Sept. 1961, Journal Name: Proc. Internat. Symposium Tissue Transplantation, Santiago, Chile, 20 Aug.-2 Sept. 1961
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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