INVESTIGATIONS OF THE INCORPORATION OF RADIOACTIVE SULFUR (S$sup 35$) IN UTERINE SECRETIONS

Journal Article · Fri Feb 01 04:00:00 EST 1963 · Geburtsh. Frauenheilk

OSTI ID:4699124

Rodriguez-Galindo, M

Radioautographic studies were made in the guinea pig after intraperitoneal injection of S/sup 35/-sulfate. In ovariectomized animals no uptake of radioactivity was detected in endometrial stroma and epithelium 24 hr after the injection; the depression of S/sup 35/ uptake was associated with atrophy of the tissue elements. Attempts were made to determine the minimum dose of estrogen required to restore S/sup 35/ uptake in uterine structures. The smallest dose of estradiol benzoate given as a single injection able to restore uptake by endometrium was 0.01 mg. With this dose, S/sup 35/ was incorporated by the 15th day after its injection, but not before. With larger doses (0.1 to 0.25 mg), S/sup 35/ appeared in the stroma and in the secreted mucus. Injection of 0.25 mg estradiol benzoate followed by 10 mg progesterone or 10 mg testosterone markedly increased the concentration of S/sup 35/ in endometrial glands and stroma and in mucus secreted into the uterine lumen. The results show the important role of estrogen in the formation and secretion of uterine mucopolysaccharides. (H.H.D.)

• Research Organization: Universitaets-Frauenklinik, Cologne
• NSA Number: NSA-17-027034
• OSTI ID: 4699124
• Journal Information: Geburtsh. Frauenheilk, Journal Name: Geburtsh. Frauenheilk Vol. Vol: 23
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
ESTROGENS
GONADS
GUINEA PIGS
HORMONES
METABOLISM
RADIOAUTOGRAPHY
SEX
STEROIDS
SULFATES
SURGERY
TISSUES
TRACER TECHNIQUES
UTERUS