THE TISSUE DISTRIBUTION AND EXCRETION OF CESIUM-137 FOLLOWING INHALATION PRELIMINARY DATA FOR RATS. Technical Progress Report
Data were obtained for the distribution-excretion patiern of cesium in rats over a period of 102 days following inhalation exposure. Three groups of 20 rats each were exposed to aerosols generated from solutions of carrier-free, 1 and 8 per cent cesium chloride which contained cesium137 as a tracer. Urine and feces of all rats were collected daily until sacrifice, and the time-tissue distribution patterns were determined after death. All measurements were made by gamma counting with sodium iodide crystals. Cesium chloride, being extremely soluble, was absorbed rapidly from the lungs and the digestive tract and the amount initiaily deposited in lung was reduced to less than 1 per cent during the first post-exposure day. The initial deposition in the lung was dependent on the aerosol particle size which was varied by the addition of the cesium chloride carrier; more lung deposition occurred with the smallest particle sizes. After the first day, the skeletal muscle and skin contained the largest amounts of this fission product but severai organs such as lung and kidney had approximately the same concentrations. Because of lack of significant amounts of radioactivity at the later sacrifice times, no definite decision could be made regarding the choice of one critical organ for greatest radiation effect. Total excretion of Cs/sup 137/ displayed an early rapid phase followed by two successively slower phases, presumably the entire pattern being fit by an exponential function. These three phases, obtained from the whole body retention curve, can be resolved into half-lives of approximately 0.6, 7.0, and 18.7 days. The importance of interspecies comparison in obtaining parameters for estimating hazards to man is discussed, using cesium metabolism as an example. (auth)
- Research Organization:
- Lovelace Foundation for Medical Education and Research, Albuquerque, N. Mex.
- DOE Contract Number:
- AT(29-2)-1013
- NSA Number:
- NSA-17-028643
- OSTI ID:
- 4695086
- Report Number(s):
- LF-4
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ADSORPTION
AEROSOLS
CESIUM
CESIUM 137
CESIUM CHLORIDES
CRYSTALS
DIAGRAMS
DIFFUSION
DISTRIBUTION
FISSION PRODUCTS
GAMMA DETECTION
GRAIN SIZE
HALF-LIFE
INTESTINE
KIDNEYS
LUNGS
MAN
MEASURED VALUES
METABOLISM
MUSCLES
PARTICLES
QUANTITATIVE ANALYSIS
QUANTITY RATIO
RADIATION EFFECTS
RADIATION INJURIES
RADIOACTIVITY
RATS
SAMPLING
SKIN
SODIUM IODIDES
SOLUBILITY
SOLUTIONS
STANDARDS
STOMACH
TISSUES
TRACER TECHNIQUES
URINE