THE COURSE OF RADIATION SICKNESS IN CHANGED REACTIVITY OF THE CENTRAL NERVOUS SYSTEM

Journal Article · Fri Jan 01 04:00:00 EST 1960 · Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr.

OSTI ID:4693694

Arutyunyan, R K

An investigation was carried out on the effect of sulfazine (1% oily emulsion of sulfur) used as a cerebral stimulant in psychiatric patients, upon the electroencephalogram of rabbits suffering from acute radiation sickness. Electrodes were implanted beneath the visual cortex in 28 rabbits, 24 of which were then subjected to x-irradiation in a dose of 900 r. Eight irradiated rabbits were observed as controls. The electroencephalogram showed increased voltage in response to an interrupted light stimulator, followed after 1 week by reduced voltage and reduced ability to assimilate the rhythm of the stimulator. Eight other rabbits were given 2 intramuscular injections of 2 ml of sulphazine with an interval of 24 hours, followed 1 hour later by irradiation. The injections each provoked pyrexia, leucocytosis, and an increase in the reactivity of the brain. High frequencies (up to 22 cycles) of the stimuiator were assimilated, but the ability to assimilate low frequencies was reduced. After 7 days voltages were reduced and assimilation of the imposed frequency was impaired. Six rabbits died after 5 to 9 days, and one after 28 days. In a third group of 8 rabbits, the two doses of sulphazine were given 1 hour and 7 days after irradiation respectively. After the first injection the potentials were increased and rapid rhythnis appeared; after the second injection slow waves (3 to 5/sec) appeared, with a transient increase in voltages. The frequency of the light stimulator was assimilated only up to 10 to 12 cycles. These changes persisted for 2 to 3 days and then returned to normal. Four rabbits died after 23 to 28 days. The 4 rabbits not irradiated acted as controls of the effect of sulphazine. (OTS)

• Research Organization: Radiobiological Section, Academy of Sciences, Armenian SSR
• NSA Number: NSA-17-030442
• OSTI ID: 4693694
• Journal Information: Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr., Journal Name: Vop. Radiobiol., Akad. Nauk Arm. SSR, Sektor Radiobiol., Sb. Tr. Vol. Vol: 1
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

BIOLOGY AND MEDICINE
BRAIN
ELECTRIC POTENTIAL
ELECTRODES
EMULSIONS
FREQUENCY
LEUCOCYTES
LIGHT
MAN
MEDICINE
MUSCLES
ORGANIC ACIDS
QUANTITY RATIO
RABBITS
RADIATION DOSES
RADIATION SICKNESS
SENSITIVITY
SULFONAMIDES
SULFUR
SURVIVAL TIME
TEMPERATURE
VARIATIONS
X RADIATION