The MAS proto-oncogene is not imprinted in humans

Journal Article · Mon Jul 15 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0372· OSTI ID:469047

Riesewijk, A M; Schepens, M T; Mariman, E M ^[1]

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1. Univ. Hospital Nijmegen (Netherlands); and others

Recently it was shown that the murine Mas gene, which is located less than 300 kb from the imprinted Igf2r gene, is also imprinted in Day 11.5 embryos with expression exclusively from the paternal allele. We have assigned the human MAS gene to chromosomal bands 6q25.3-q26 in close proximity to the IGF2R gene. In contrast to its murine homologue, the human IGF2R gene is not imprinted. By making use of a novel intragenic polymorphism, we have studied the expression of the MAS gene in three heterozygous human fetuses. In all tissues examined, including tongue, biallelic expression of the MAS gene was observed. Hence both MAS and the neighboring IGF2R gene are not imprinted in humans. 20 refs., 1 fig., 1 tab.

• OSTI ID: 469047
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 2 Vol. 35; ISSN GNMCEP; ISSN 0888-7543
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL EVOLUTION
CHROMOSOMES
DNA SEQUENCING
FETUSES
GENE MUTATIONS
GENE REGULATION
GENETIC MAPPING
HUMAN CHROMOSOME 6
MICE
NUCLEOTIDES
ONCOGENES
POLYMERASE CHAIN REACTION
SEX DEPENDENCE
TRANSCRIPTION