PARTICIPATION OF THE COAGULATION MECHANISM IN TUMOR LOCALIZATION OF I$sup 131$-LABELLED FIBRINOGEN
A transplantable tumor of the rat, the Murphy-Sturm lymphosarcoma, was found to contain 15 to 25% of the adminlstered radioactive dose 18 hours after intravenous injection of I/sup 131/-labeled rat fibrinogen in a rat bearing a tumor in the 2 to 12 gm weight range. At this time the concentration of radioactivity per gm of tumor was found to be some 4 to 15 times that of such vascular organs as the liver and kidney, smaller tumors (2 to 5 gm) localizing much more of the injected radioactive dose per gm than larger tumors (8 to 12 gm). These tumors did not concentrate radioactivity after intravenous injection of either I/sup 131/ gamma -globulin or inorganic NaI/sup 131/. The administration of heparin or warfarin in dosages adequate to completely inhibit the blood coagulation mechanism throughout the 18-hour experimental period decreased this specific tumor localization of I/sup 131/ fibrinogen by 60 to 80%. It is concluded that the coagulation mechanism participates in the localization of I/ sup 131/ fibrinogen in the Murphy-Sturm lymphosarcoma. Physiological mechanisms of action other than the anticoagulative one which could possibly explain the effect of heparin and warfarin on tumor localization are discussed. No experimental evidence for an enhancement of fibrinolysis as the mechanism of tumor I/sup 131/ localization decrease by the drugs was found. In particular, these anticoagulants did not decrease whole--body radioactivity retention, and the radioactivity retained in the tumor-bearing rats receiving anticoagulant was highly clottable 18 hours after injection of I/sup 131/ fibrinogen. (auth)
- Research Organization:
- Rochester, N.Y. Univ. Atomic Energy Project
- DOE Contract Number:
- W-7405-ENG-49
- NSA Number:
- NSA-17-031820
- OSTI ID:
- 4683695
- Report Number(s):
- UR-630
- Resource Relation:
- Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- United States
- Language:
- English
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BLOOD
BLOOD VESSELS
BODY
CANCER
CHEMICAL REACTIONS
COAGULATION
DISTRIBUTION
DRUGS
FIBRINOGEN
FIBRINOLYSIS
GLOBULINS
HEPARIN
IODINE 131
KIDNEYS
LABELLED COMPOUNDS
LIVER
LYMPH SYSTEM
LYMPHOSARCOMAS
PHYSIOLOGY
PROTEINS
QUANTITY RATIO
RADIATION DOSES
RADIOACTIVITY
RATS
SODIUM IODIDES
TRANSPLANTS
TUMORS
VARIATIONS
WEIGHT