DEPENDENCE OF THE FREQUENCY OF OCCURRENCE OF RECESSIVE SEX-LINKED LETHAL MUTATIONS IN DROSOPHILA SPERMATOGENESIS ON THE FAST-NEUTRON DOSE

Journal Article · Tue Jan 01 04:00:00 EST 1963 · Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.)

OSTI ID:4682671

Abeleva, E A; Lapkin, Yu A

Experiments carried out to clarify the fast-neutron-dose dependence of the occurrence frequency of dominant lethal mutations were inconclusive. The difference between the frequencies in spermatids and sperm with neutron irradiation was less than in gamma and x irradiation. The dependence on dose in the range 1200-2400 rad tapered off, as in gamma irradiation, but the absolute frequency was so high that it was explained by the reaching of the limits of possible occurrence of the given type of mutation. To determine if hidden factors are involved or if the nature of the mutations caused by fast neutrons in spermatids is similar to that in low-ionizing radiation, the recessive sex-linked lethal mutations were studied, which are less frequent than the dominant. Comparison of the data obtained with earlier data showed that the ratios between the frequencies of mutation in spermatids and sperm in neutron-irradiation at 1000 rad are the same for l000-r gamma radiation, that is, 2.27 and 2.16, respectively. In the 1000- to 2000-r range the frequency of mutation occurrence was proportional to the 0.57 power of the dose with gamma irradiation and to the 0.37 power with neutron irradiation. (TTT)

• Research Organization: Inst. of Biological Physics, Moscow
• NSA Number: NSA-17-031936
• OSTI ID: 4682671
• Journal Information: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.), Journal Name: Radiobiologiya (U.S.S.R.) For English translation see Radiobiology (Engl. Transl.) Vol. Vol: 3; ISSN RADOA
• Country of Publication: Country unknown/Code not available
• Language: Russian

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BIOLOGY AND MEDICINE