SOME CHARACTERISTICS OF THE HIGHER NERVOUS ACTIVITY OF ANIMALS EXPOSED TO IONIZING RADIATION IN UTERO. V. CHARACTERISTICS OF THE HIGHER NERVOUS ACTIVITY IN EARLY POSTNATAL ONTOGENESIS IN PUPPIES IRRADIATED DURING EMBRYONIC DEVELOPMENT
Journal Article
·
· Byul. Eksperim. Biol. i Med.
OSTI ID:4678145
Six bitches were totally irradiated with 200 r x rays on the 20th or 45th day of pregnancy or were left untreated. Puppies from irradiated bitches showed a number of vegetative nervous disorders from the first days of life, pulse and respiration rates increased, and urination, defecation, and regurgitation were frequent. Development was uneven and retarded in all but 1; the variation in weight between individuals was up to 15%, compared with 10 to 15% in controls. Leucopenia occurred in trial puppies especially in those irradiated as 45-day embryos. At birth and up to 30 days of age they had fewer red cells per mm/sup 3/ blood. Hb fell in both groups, most in trial puppies, especially after irradiation at 45 days in utero when the values fell by about 50%. In all controls a conditioned olfactory motor feeding reflex was formed on the 1st day; in trial puppies it occurred somewhat more slowly and with a mixed response. Intensity, duration, and direction of motor reactions in response to the smell of camphor were considerably more distinct in controls. When conditioned reflex activity was studied by the shaking method from the 10th day reflexes, especially differentiation, appeared in the trial puppies. Data from both methods show that from birth to 2 months the closing function of the cerebral cortex in puppies irradiated in utero was considerably weaker than in controls. Occurrence of paradoxic and ultraparadoxic reactions indicated a low level of activity in the cortex cells. There were similar changes in higher nervous activity in both groups of irradiated puppies, but neurodynamic disturbances, especially the processes of internal inhibition, were more marked in those irradiated on the 45th day in utero. (OTS)
- Research Organization:
- Inst. of Higher Nervous Activity and Neurophysiology, Moscow
- NSA Number:
- NSA-17-030401
- OSTI ID:
- 4678145
- Journal Information:
- Byul. Eksperim. Biol. i Med., Journal Name: Byul. Eksperim. Biol. i Med. Vol. Vol: 55
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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· Meditsinskaya Radiologiya (U.S.S.R.) For English translation see Med. Radiol., USSR
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OSTI ID:4247800