Genetic Effects of Strontium-90 on Immature Germ-cells in Mice

Journal Article · Sat Jul 20 04:00:00 EDT 1963 · Nature (London)

DOI:https://doi.org/10.1038/199303a0· OSTI ID:4671555

LÜNING, K. G.; FRÖLÉN, H.; NELSON, A.; RÖNNBÄCK, C.

To determine the effects of Sr/sup 90/ injection on mouse spermatogonia, male mice (strain CBA) were injected with Sr/sup 90/ and mated to virgin females from the 10th up to the 15th week afterwards. Females mated the 10th week were allowed to give birth to their litters to produce F/sub 1/ animals for further tests. Females mated on the 11th to 15th weeks were killed for analysis of lethality among fetuses. It was evident that effects of Sr/sup 90/ on spermatogonia caused an increase in intra-uterine death. From this and previous experiments, it was shown that Sr/sup 90/ injected into male mice causes dominant lethality in all stages of spermatogenesis. The effects of Sr/sup 90/ injected into females was then investigated, and a slightly higher intra-uterine death rate appeared. Effects of dominant lethality on F/sub 2/ and following generations were studied. It was indicated that there is no considerable rate of recessive lethals. (H.M.G.)

• Research Organization: Research Inst. of National Defence, Sundyberg, Sweden
• Sponsoring Organization: USDOE
• NSA Number: NSA-17-033713
• OSTI ID: 4671555
• Journal Information: Nature (London), Journal Name: Nature (London) Journal Issue: 4890 Vol. 199; ISSN 0028-0836
• Publisher: Nature Publishing Group
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

ANIMAL CELLS
BIOLOGY AND MEDICINE
CHROMOSOMES
FETUSES
GENETICS
GONADS
MICE
MUTATIONS
PREGNANCY
RADIATION INJURIES
RADIATIONS
REPRODUCTION
SEX
SPERMATOGONIA
STRONTIUM 90