THE OSMOTIC RESISTANCE OF LEUKOCYTES AFTER ROENTGEN IRRADIATION (in German)
Surviving peripheral leukocytes from human, dog, and rabbit blood and from rat ascitic fluid were irradiated in vitro with 50 to 50,000 r doses of x rays, and osmotic resistance was tested by shaking with 0.30% saline solution. When whole blood was irradiated, doses of 1000 r and below did not appreciably affect resistance. However, above this dose a dose-dependent decline in resistance, after a short latent period, was noted. This fall in resistance was greater when the cells were irradiated in saline suspension, rather than in whole blood, and greatest when masses of washed unsuspended cells were irradiated. It was more marked when the cells were irradiated during suspension in previously irradiated plasma than in normal plasma, although irradiated plasma offered more protection to the leukocytes than saline. Since it has been proposed by Ludany that a plasma radioprotective factor arises from duodenal acidification, osmotic resistance of leukocytes was tested in the blood of dogs intraduodenally infused with 5 ml 0.1N hydrochloric acid. When the blood was drawn 25 min after this procedure was carried out, increased resistance of the leukocytes was demonstrable. (BBB)
- Research Organization:
- Military Hospital, Budapest
- NSA Number:
- NSA-17-035584
- OSTI ID:
- 4668256
- Journal Information:
- Z. Ges. Inn. Med. Ihre Grenzgebiete, Journal Name: Z. Ges. Inn. Med. Ihre Grenzgebiete Vol. Vol: 17
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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