LONG-TERM RAT FEEDING STUDIES ON IRRADIATED CHICKEN STEW AND IRRADIATED CABBAGE
S>Chicken stew was exposed to sterilizing doses of Co/sup 60/ gamma radiation and cabbage to pasteurizing doses. Evaluation for wholesomeness was made by feeding to four successive generations of rats. The stew (0, 2.79, and 5.58 Mrad) and raw cabbage (0, 279, and 558 krad) were combined, each at 35% of the final diet solids, with other nonirradiated ingredients to provide a nutritionally adequate ration. Before use in diet preparation, the irradiated chicken stew was stored at 75 deg F, control stew at 5 deg F for 3-6 months, and both irradiated and control cabbage at 35-40 deg F for 2-4 weeks. Soon after weaning, parent-generation rats were then given the diets for 104 weeks: succeeding generations were fed for shorter periods. Growth of parent-generation rats was not influenced by the irradiated foods, nor generally that of second- and third-generation animals. No effects were observed on the reproductive performance of three generations or on longevity of parent-generation animals. Pathologic and hematologic findings were similar in test and control animals. Rats fed both foods treated with max dose manifested the following significant changes in duodenal enzymes: decreased levels for alkaline phosphatase in both sexes and monoamine oxidase in females, increased alanyl- BETA -aminopeptidase and 2-naphthyl octanoate esterase activity in females. Sucrase, glutamic- oxalacetic and glutamic-pyruvic transaminases were unaffected by feeding irradiated foods. In contrast to these results on young rats, adult animals given the irradiated food failed to show any effects upon intestinal mucosal levels of hexokinase, sucrase, alkaline phosphatase, and glutamicoxalacetic transaminase. The incidence of tumors was similar in both experimental and control groups. It is concluded that growing rats are inore sensitive than adult rats to factors that alter tissue enzyme activities. (H.H.D.)
- Research Organization:
- Univ. of Syracuse, N.Y.
- NSA Number:
- NSA-17-034200
- OSTI ID:
- 4668094
- Journal Information:
- Toxicology and Applied Pharmacology (U.S.), Journal Name: Toxicology and Applied Pharmacology (U.S.) Vol. Vol: 5; ISSN TXAPA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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IRRADIATED CHICKEN STEW AND CABBAGE DIET--REPORT OF OBSERVATIONS ON NUTRITION, RADIATION AND STERILIZATION OF FOODS FOR BIOLOGICAL RESEARCH LABORATORIES, SYRACUSE UNIVERSITY RESEARCH INSTITUTE, SYRACUSE, NEW YORK
LONG-TERM FEEDING OF IRRADIATED CHICKEN STEW AND COLESLAW TO RATS. Progress Report No. 4 for September 15, 1958 to March 15, 1959