High-resolution mapping of a 130-kb core region of the MYCN amplicon in neuroblastomas
- Washington Univ. School of Medicine, St. Louis, MO (United States)
This article reports on a high-resolution restriction map containing the MYCN locus. the exon-intron structure and tissue distribution of the laminin {gamma}2 chain (LAMC2) gene, which is mutated in some cases of junctional epidermolysis bullosa. The article also discusses the transcription and splicing of this gene, which result in alternative uses of the last two exons of the gene. The different tissue distributions of the transcripts indicate different functions for the gene in vivo. 36 refs., 8 figs., 3 tabs.
- OSTI ID:
- 466400
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 32; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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