Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0345· OSTI ID:466041

Monte, D; Coutte, L; Dewitte, F ^[1]

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1. CNRS URA, Lille (France); and others

The ERM protein belongs to the family of Ets transcription factors. We show here that the human ERM gene is organized into 14 exons distributed along 65 kb of genomic DNA on chromosome 3. The two main functional domains of ERM, the acidic domain and the DNA-binding ETS domain, are overlapped by three different exons each. The 3{prime}-untranslated region of ERM is 2.1 kb, whereas the 5{prime}-untranslated region is about 0.3 kb; this allows the transcription of ERM transcripts of approximately 4 kb. The human ERM gene is localized to the q27-q29 region of chromosome 3. 17 refs., 3 figs.

• OSTI ID: 466041
• Journal Information: Genomics, Vol. 35, Issue 1; Other Information: PBD: 1 Jul 1996
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
TRANSCRIPTION FACTORS
STRUCTURE-ACTIVITY RELATIONSHIPS
TRANSCRIPTION
GENETIC MAPPING
DNA SEQUENCING
HUMAN CHROMOSOME 3
PROTEINS
IN-SITU HYBRIDIZATION
EXONS
PROBES
NUCLEOTIDES
POLYMERASE CHAIN REACTION