Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement

Journal Article · Mon Jul 01 04:00:00 EDT 1996 · Genomics

DOI:https://doi.org/10.1006/geno.1996.0323· OSTI ID:466019

Wilcox, S A; Watson, J M; Spencer, J A ^[1]

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1. La Trobe Univ., Victoria (Australia); and others

Previous comparisons of gene location in the three major groups of mammals (eutherians, marsupials, and monotremes) have suggested that the long arm of the human X represents the ancestral mammalian X chromosome, whereas the short arm represents an autosomal region(s) recently added to the eutherian X chromosome. To identify the fusion point of this ancient X-autosome rearrangement, we have mapped four genes, three of which map near the centromere of the human Xp, in marsupials and in a monotreme. We found that ARAF1, and GATA1 are located on the X chromosome in marsupials, and ALA2 and GATA1 are also located on the X in the platypus. This implies that the proximal short arm of the human X chromosome, including the centromere, was part of the ancestral mammalian X chromosome. The fusion point between the conserved region and the recently added regions therefore maps to human Xp11.23, although gene order on the human X indicates that there has been some rearrangement of this region. 26 refs., 3 figs., 1 tab.

• OSTI ID: 466019
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 35; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL EVOLUTION
CENTROMERES
COMPARATIVE EVALUATIONS
GENES
GENETIC MAPPING
HUMAN X CHROMOSOME
HYBRIDIZATION
IN-SITU HYBRIDIZATION
MAMMALS
MARSUPIALS
SOMATIC CELLS
STRUCTURE-ACTIVITY RELATIONSHIPS