INFLUENCE OF THE ADMINISTRATION OF RADIOACTIVE PHOSPHORUS (P$sup 32$) ON THE GENITAL APPARATUS OF PUBERTAL AND PREPUBERTAL RATS (in Italian)
Journal Article
·
· Arch. Ostet. Ginecol.
OSTI ID:4659005
Prepubertal (30-day-old) and pubertal (150-g) female rats were injected subcutaneously with 3 to 6 mu C/g doses of P/sup 32/-orthophosphate and sacrificed up to 60 days later. The young rats were given two injections spaced 8 days apart and the older rats a single injection of isotope. A third group of adult female rats were given 3.5 or 7 mu C/g and examined 6, 12, and 30 days later. Body wt loss was observed in all three groups of rats receiving the isotope. Fertility and histologic changes in ovary and uterus were studied. Ovaries were smaller in rats receiving P/sup 32/ and the granulosa cells of developing follicles showed cytoplasmic vacuolation and pyknosis. In some follicles mitoses were more numerous than in controls. These changes were present after the low dose; after the higher dose, atretic follicles were present and corpora lutea completely lacking. Minimal changes were noted in the uteri of treated prepubertal rats, including a flattening of epithelium of endometrium and an increased muscle/connective tissue ratio of myometrium. Pubertal rats treated with the higher dose showed progressive anorexia, asthenia, ruffling of the fur, and hemorrhagic crusts about the eyes and nose, followed by death. These rats also revealed follicular atresia, which was more severe with the higher dose. Of the adult female rats treated with P/sup 32/, only 1 out of 30 became pregnant after mating, and 8 of the 13 fetuses showed arrested development and resorption. This is in contrast to a pregnancy rate of 50% in rats not treated with P/sup 32/ and a mean fetal count of nine per animal. Ovaries and uteri from this group showed histopathologic changes resembling those seen in the other two groups. The results demonstrate the high sensitivity of the graffian follicle to irradiation by P/sup 32/. (BBB)
- Research Organization:
- Universita, Palermo, Italy
- NSA Number:
- NSA-17-035473
- OSTI ID:
- 4659005
- Journal Information:
- Arch. Ostet. Ginecol., Journal Name: Arch. Ostet. Ginecol. Vol. Vol: 66
- Country of Publication:
- Country unknown/Code not available
- Language:
- Italian
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