INTERNAL IRRADIATION OF PARENCHYMATOUS ORGANS BY INJECTION OF COLLOIDAL Au$sup 198$ INTO THE MAIN DUCT: A NEW METHOD FOR IRRADIATING NEOPLASMS OF THE LIVER, PANCREAS, AND PAROTID
In order to obtain homogeneous irradiation of a particular organ over a long period, it is desirable for the substance injected to become evenly distributed in the organ itself and to be fixed within the cells. This can be achieved only by causing the isotope to circulate exclusively in the organ to be irradiated and not in the general circulation. It was previously noted that colloidal gold injected into the parotid duct becomes concentrated in the nucleus, mitochondria, and in the infra- and supranuclear canalicular system of the parotid cells, suggesting that it is possible to obtain an even distribution of irradiation in glandular organs by injecting colloidal radiogold into a duct. A radioautographic study of the distribution of colloidal gold injected into various organs through a duct or vein was made by injecting 200 mu c colloidal Au/sup 198/ into the hepatic artery, portal vein, and common bile duct of rabbits which were then sacrificed after 72 hr. In other rabbits, 160 mu c colloidal Au/ sup 198/ was injected into the duct of the pancreas. Two mu c/g were injected into the duct of the parotid and pancreas taken from the rabbit, dog, calf, and man. Injection of colloidal Au/sup 198/ into the pancreatic duct of the rabbit, calf, and man was followed by a high and even concentration of radioactivity over the entire surface of the gland. When radiogold was injected into the pancreatic duct, radioactivity in liver, spleen, and lungs was only slightly higher than the background radioactivity; most of the radioactivity remained in the pancreas even 72 hr after injection. Confirmation by radioautography showed a total absence of radioactivity in the lungs, liver, and spleen, and 72 hr after injection the radioactivity in pancreas remained high and uniformly distributed over the entire gland. Similarly, after injecting colloidal Au/sup 198/ into the liver, the liver contained a high concentration of radioactivity three days later in every case, whether injection had been through the hepatic artery, portal vein, or common bile duct. Whatever the route of injection, spleen always contained radioactivity, though it was very little when the Au was injected into the common duct. It is concluded that the best way of fixing colloidal radioactive substances in the liver is by injecting them into the common duct and that it is possible to achieve internal irradiation of a gland by injecting colloidal radiogold into the main duct. It should thus be possible to irradiate pancreas and salivary glands as well as the liver by introducing radioactive substances in such a way as to enter their parenchymal cells and act on the nuclei. (TCO)
- Research Organization:
- Universita, Turin
- NSA Number:
- NSA-17-033501
- OSTI ID:
- 4655391
- Journal Information:
- Panminerva Medica (Italy), Journal Name: Panminerva Medica (Italy) Vol. Vol: 3; ISSN PMMDA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
Similar Records
STUDIES ON THE UPTAKE OF Au$sup 19$$sup 8$
Dynamic studies on the portal hemodynamics by scintiphotosplenoportography. Streamline flow in the human portal vein