LOCAL IRRADIATION OF THE THYMUS. HISTOLOGIC CHANGES WITH OBSERVATIONS ON CIRCULATING LYMPHOCYTES AND SERUM PROTEIN FRACTIONS IN ADULT MICE
Journal Article
·
· American Journal of Pathology (U.S.)
OSTI ID:4646367
ABS>Shortly following local irradiation of the thymic region in adult C/ sub 3/H mice with 3000 r tissue dose, in one exposure, there occurred a marked decrease in the number of circulating lymphocytes associated with an almost complete disappearance of the lymphocytic population of the thymus. Subsequent repopulation of the thymus was accompanied by a return of the lymphocyte count to pre-irradiation levels. Plasma cells and other pyroninophilic lymphoic cells appeared in large numbers in the thymus and mediastinal lymph nodes 2 weeks following local irradiation of the thymic region. This finding was associated with a significant rise of serum gamma globulin concentration. It is suggested that these results indicate an immune response to antigenic byproducts of irradiation. (auth)
- Research Organization:
- Columbia Univ., New York; Francis Delafield Hospital, New York
- NSA Number:
- NSA-17-035467
- OSTI ID:
- 4646367
- Journal Information:
- American Journal of Pathology (U.S.), Journal Name: American Journal of Pathology (U.S.) Vol. Vol: 43; ISSN AJPAA
- Country of Publication:
- Country unknown/Code not available
- Language:
- English
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