LOCAL IRRADIATION OF THE THYMUS. HISTOLOGIC CHANGES WITH OBSERVATIONS ON CIRCULATING LYMPHOCYTES AND SERUM PROTEIN FRACTIONS IN ADULT MICE

Journal Article · Sun Sep 01 00:00:00 EDT 1963 · American Journal of Pathology (U.S.)

OSTI ID:4646367

Ghossein, N A; Azar, H A; Williams, J

ABS>Shortly following local irradiation of the thymic region in adult C/ sub 3/H mice with 3000 r tissue dose, in one exposure, there occurred a marked decrease in the number of circulating lymphocytes associated with an almost complete disappearance of the lymphocytic population of the thymus. Subsequent repopulation of the thymus was accompanied by a return of the lymphocyte count to pre-irradiation levels. Plasma cells and other pyroninophilic lymphoic cells appeared in large numbers in the thymus and mediastinal lymph nodes 2 weeks following local irradiation of the thymic region. This finding was associated with a significant rise of serum gamma globulin concentration. It is suggested that these results indicate an immune response to antigenic byproducts of irradiation. (auth)

• Research Organization: Columbia Univ., New York; Francis Delafield Hospital, New York
• NSA Number: NSA-17-035467
• OSTI ID: 4646367
• Journal Information: American Journal of Pathology (U.S.), Journal Name: American Journal of Pathology (U.S.) Vol. Vol: 43; ISSN AJPAA
• Country of Publication: Country unknown/Code not available
• Language: English

Related Subjects

AGE
ANTIGENS
BIOLOGY AND MEDICINE
BLOOD SERUM
GLOBULINS
IMMUNITY
IRRADIATION
LYMPH SYSTEM
LYMPHOCYTES
MICE
QUANTITY RATIO
RADIATION DOSES
RECOVERY
THYMUS
TISSUES