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EFFECT OF MODERATE DEGREES OF HYPOTHERMIA ON THE SENSITIVITY TO WHOLE-BODY IRRADIATION IN ADULT RATS

Journal Article · · Radiation Res.
DOI:https://doi.org/10.2307/3571526· OSTI ID:4646199
Adult female CFN/sup 3/ rats were cooled to a body temperature of 25 deg C by immersion in a water bath. The animals were maintained in a hypothermic state for eight hours before irradiation. A lethal dose of 900 r of x radiation was administered at room temperature after whlch body temperature was gradually returned to normal. All animals that were hypothermic when irradiated survived at least five months, whereas those not hypothermic when irradiated were all dead within 13 days. Animals subjected to hypothermia alone showed no ill effects. Possible mecharrisms of hypothermic protection are discussed. (H.M.G.)
Research Organization:
Bowman Gray School of Medicine, Winston-Salem, N.C.
Sponsoring Organization:
USDOE
NSA Number:
NSA-17-040609
OSTI ID:
4646199
Journal Information:
Radiation Res., Journal Name: Radiation Res. Vol. Vol: 20
Country of Publication:
Country unknown/Code not available
Language:
English