COMPARATIVE DETERMINATION OF BLOOD VOLUME WITH EVANS BLUE AND Cr$sup 51$ IN HEALTHY SUBJECTS AND POLYCYTHEMIA PATIENTS TREATED WITH P$sup 3$$sup 2$ (in German)
Blood volume was determined by the Evans blue and the Cr/sup 51/ methods in 40 normals and 17 cases of polycythemia. In normals there was good agreement of the results of both methods, however, in polycythemia differences were observed. With the Crsl-method the erythrocyte volume was found to be lower than with the Evans blue technique although the difference was not significant. When the active circulating blood volume is determined, the introduction of a correction factor for the so-called body hematocrit is not necessary. lt is possible that the difference between venous hematocrit and the quotient Evans blueplasma volume/Cr/sup 51/ erythrocyte volume is caused by an increase of the error due to the trapped plasma. In case with increased hematocrit values the plasma volume should be determined by Evans blue and the erythrocyte volume by Cr/ sup 51/. In polycythemia the mean values were lower the those previously estimated by Seyderheim and Lampe. In the untreated state of polycythemia the mean plasma volume is reduced; in 80% of the cases a reduction was found initially. With successful treatment the plasma volume increased. Treatment consisted of injection of 0.08-0.09 mC P/sup 32/ per kg body wt, which was repeated three months later if necessary. Half the patients required only one such dose for remission; only one required three doses. Improvement in plasma volume showed no correlation with the size of the spleen or the presence of hypertension. The venous pressure was normal in all cases. Circulation time was variable but showed a tendency to become shorter following treatment with P/sup 32/. Renal function studies are discussed. Creatinine-clearance and phenolsulfonphthalein (PSP) excretion were often reduced, and albuminuria, hematuria, and azotemia were present. With clinical improvement after P/sup 32/ treatment these symptoms are reversible except for the reduced PSP excretion. (BBB)
- Research Organization:
- Universitat, Wurzburg, Ger.
- NSA Number:
- NSA-17-035398
- OSTI ID:
- 4642143
- Journal Information:
- Z. Klin. Med., Vol. Vol: 157; Other Information: Orig. Receipt Date: 31-DEC-63
- Country of Publication:
- Country unknown/Code not available
- Language:
- German
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Related Subjects
ALBUMINS
BLOOD CIRCULATION
BLOOD PLASMA
CHROMIUM 51
CREATININE
DISEASES
DYES
ERYTHROCYTES
EVANS BLUE
HYPERTENSION
KIDNEYS
MAN
MEASURED VALUES
METABOLISM
NITROGEN
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PHENOLPHTHALEIN
PHOSPHORUS 32
PROTEINS
RADIOTHERAPY
SPLEEN
TRACER TECHNIQUES
URINE